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Blepha EyeBag® | Warming Eye Mask | Relief of Dry, Tired and Sore Eyes | Microwaveable | Previously the MGDRx® EyeBag

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The EyeBag ® Instant (The Eyebag Company, Halifax, UK) is a single-use, disposable warm compress. It is activated by air; therefore, it starts to heat 2–3 min after the mask is removed from the sachet, and it can be placed on the eyelids for 10 min [ 20]. Satjawatcharaphong P, Ge S, Lin MC. Clinical outcomes associated with thermal pulsation system treatment. Optom Vis Sci. 2015;92(9):334–41. EyeBag puede aliviar los síntomas del ojo seco, pero el efecto sobre la función de las glándulas de Meibomio y la estabilidad de la lágrima al utilizarse durante 4 semanas fue indetectable. These devices remove the bacterial biofilm, debris, and scurf present in the MG ducts, which could occlude them and therefore prevent meibum delivery.

In the edges of the upper and lower eyelids there are small glands, known as the Meibomian glands. These glands secrete an oily substance needed to lubricate and clean the front of the eye and allow the tear film to spread effectively.The Blepha EyeBag (Formally MDG Rx Eyebag ®) is a patented, CE marked Class 1 medical device registered with the Medicines and Healthcare products Regulatory Agency (MHRA). The Blepha EyeBag is a silk and suedex device which can be re-heated up to 200 times in a microwave. Simply heat for 30 or 40 seconds on full power and the Blepha EyeBag will stay warm for up to 10 minutes. If this is the only way of heating your EyeBag, ensure that you place it in a clean closed ovenproof container with a well fitting lid.

Jester J.V., Nicolaides N., Kiss-Palvolgyi I., Smith R.E. Meibomian gland dysfunction. II. The role of keratinization in a rabbit model of MGD. Investigative Ophthalmology & Visual Science. 1989;30:936–945. Leave the EyeBag on the Radiator for half an hour turning and shaking form time to time to obtain even and thorough warming. Thirty young, healthily volunteers between 18 and 31 years of age (23.95±3.94 years) and thirty older subjects between 61 and 90 years of age (77.97±8.11 years) participated in this study. Ocular surface parameters were assessed using the Oculus Keratograph 5M, following the guidelines of the Tear Film and Ocular Surface Dry Eye Workshop II Diagnostic Methodology report. Only subjects with a positive score on at least one questionnaire and an initial Non-Invasive Keratograph Break-Up Time (NIKBUT) under 10seconds were included in the study. After thermal bag self-application in both eyes every day for 2 weeks, the protocol was carried out again. Lid massage was performed after lid warming. Compliance and degree of improvement were also assessed. VTP improved MG function and symptoms at 6months, but had no effect on MG atrophy; patients with severe MG atrophy responded poorly Sarman ZS, Cucen B, Yuksel N, Cengiz A, Caglar Y. Effectiveness of intraductal meibomian gland probing for obstructive meibomian gland dysfunction. Cornea. 2016;35(6):721–4.Probing improved ocular symptoms (OSDI) and TBUT for up to 3months as well as reduced hyperaemia and lid margin vascularity VTP was as effective as twice daily application of a warm compress for 3months; treatment efficacy was not affected by pre‐treatment MG loss

Founded in 2004 by consultant ophthalmologist, Professor Teifi James, The EyeBag offers a patented reusable warm compress, the MGDRx EyeBag. The compress provides a treatment for dry eye, meibomian gland dysfunction (MGD), blepharitis and associated symptoms.The MGDRx EyeBag is a simple device for heating the eyelids, resulting in increased NITBUT and TFLLT in subjects without meibomian gland dysfunction that seem to be clinically significant. Future studies are required to determine clinical efficacy and evaluate safety after long-term therapy in meibomian gland dysfunction patients. IPL plus MGX improved ocular symptoms (SPEED score) and TBUT as well as reduced the levels of inflammatory markers in tear fluid Twenty-five participants completed the study (mean age 38±15 years, 7 male). There was a significant change in OSDI over time for the EyeBag group (mean[lower 95% CI, upper 95% CI], baseline: 39.1[31.1,47.0], 2wk: 26.8[19.7,33.9], 4wk: 26.6[16.5,36.7], 8wk: 27.7[18.4,37.0]; p=0.01), but not in the control group (p=0.22), but no significant difference between groups at all time points (all p>0.27). Symptoms immediately improved after conducting the EyeBag based on at-home CSQ scores (Δ=-5.0 points, p<0.01), but not in the control group. For both groups, there was no significant change (p-value EyeBag,p-value control) in MG score (0.21,0.17) and NIBUT (0.49,0.06) over time. This was a prospective, randomized, controlled, observer-masked, bilateral eye study that enrolled 29 participants. Participants were randomized into either the EyeBag group or the control group. The EyeBag group used the EyeBag 10minutes 2x/day, and the control group remained on their own dry eye treatment regimen (if applicable). All participants were observed at baseline, 2 weeks (2wk) and 4 weeks (4wk). At 4wk, participants in the EyeBag group were asked to stop using the EyeBag. All participants were seen again at 8 weeks (8wk). Primary outcomes were the Ocular Surface Disease Index (OSDI), Current Symptoms Questionnaire (CSQ), meibomian gland score (MG score), and non-invasive tear breakup time (NIBUT). Regarding the efficacy, some studies assessed IPL treatment alone. Jiang et al. [ 73] (III) observed an improvement in symptoms, BUT, conjunctival injection, and MG score from baseline to day 45. However, no differences were found between days 75 and 45, suggesting that two sessions were enough to reduce the signs and symptoms of MGD. Vigo et al. [ 74] (III) also performed follow-up visits on day 1, 15, and 45. They found an improvement in NIBUT, LLT, and osmolarity and suggested that patients with lower BUT responded better to the treatment. Finally, Yurtasser et al. [ 75] (III) found an improvement in symptoms and NIBUT at 1 month and an improvement in symptoms, NIBUT, MG dropout, and corneal staining in the mild and moderate MG atrophy groups, lasting up to 12 months. No improvement was observed in patients with severe MG atrophy. However, another study (II) compared IPL with eyelid hygiene and found that although both groups improved in symptoms, BUT, and MG score; the IPL group also improved in conjunctival staining [ 76].

Liang Q, Liu H, Guo Y, et al. Clinical evaluation of a thermodynamic treatment system for meibomian gland dysfunction. Zhonghua Yan Ke Za Zhi. 2015;51(12):924–31. The MGDRx EyeBag ® (The Eyebag Company, Halifax, UK) is a reusable silk and cotton mask that can be heated in a microwave for 40 s. Peak temperatures (37.6 °C) may be reached after 2 min of its application on the external upper eyelids. After 12 min of treatment, temperatures may slightly decrease (36.8 °C) [ 16, 17]. Knop E, Knop N, Millar T, Obata H, Sullivan DA. The International Workshop on Meibomian Gland Dysfunction: report of the subcommittee on anatomy, physiology, and pathophysiology of the meibomian gland. Investig Opthalmol Vis Sci. 2011;52(4):1938.

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Several studies evaluated the IPL treatment along with other treatments. Piyacomn et al. [ 70] (I) observed a higher and faster improvement in the MG function in patients who combined conventional eyelid hygiene and IPL than in those patients who performed hygiene alone. Huang et al. [ 72] (I) compared IPL with intraductal MG probing. They reported that the combination of both methods was more effective than separately in improving symptoms, BUT, meibum grade, and telangiectasias. IPL alone was more suitable for relieving intraductal inflammation, while MG probing was better for patients with severe MG obstruction or MG scarring. Some studies combined IPL treatment with MG expression. While Toyos et al. [ 77] (II) only found an improvement in symptoms and BUT, Dell et al. [ 78] (III) also observed improvements in MG score and corneal staining. However, Arita et al. [ 79] conducted a randomized clinical trial (I) comparing a combined therapy and MG expression alone. They found an improvement in the symptoms, NIBUT, BUT, and MG score in both therapies. However, the improvement was higher after the combined therapy, and this group also improved the LLT and corneal staining. VTP improved MG secretion and reduced symptoms over 1year; early VTP for MGD was associated with improved treatment outcomes Badawi D. A novel system, TearCare®, for the treatment of the signs and symptoms of dry eye disease. Clin Ophthalmol. 2018;12:683–94. Eyelid warming therapy associated with eyelid massage has been suggested to induce corneal deformation due to increases in corneal temperature, and with concurrent massaging, possible ectasia. 24 Only one case of corneal deformation following such treatment has been reported, but the duration of treatment in this case was far longer (15min twice a day for 7weeks) than that prescribed herein. Transient visual degradation without changes in corneal topography has been observed after warm compresses (45°C) were applied every 2min for 30min without massage, 25 but again the duration of treatment and peak temperature was sustained for longer than the present study and the treatment method is not typically advised to MGD patients. Therefore, it appears that corneal deformation and/or visual changes, may only occur following unusually long and intense treatment application durations and long-term therapy associated with eyelid rubbing.

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